This might be for you if you notice
- A low, empty or hopeless mood that has lasted most of the day for weeks
- Losing interest in people and activities that used to matter to you
- Sleep, appetite or energy that has changed and is not settling
- Wondering whether medication, therapy or both could be worth discussing
- Living in New York and looking for medication care by video
- Taking an antidepressant and wanting someone to review how it is going
What depression treatment can include
The National Institute of Mental Health (NIMH) says depression treatment typically involves psychotherapy, medication or both. If those do not reduce symptoms enough, brain stimulation therapy may be another option. NIMH also says most people with depression benefit from treatment.
The right plan depends on your needs, your preferences and your medical situation, and it is chosen with a professional. NIMH notes that finding what works may take some trial and error. Psychotherapy is often tried first for milder depression, while people with moderate or severe depression are usually prescribed medication as part of the first plan.
Therapy approaches, and where we offer them
Therapy with our team is online and is for clients physically located in Pennsylvania, West Virginia, Arizona, Colorado or Florida during each session. It is not available with us in New York, so a New York reader can see our psychiatrist here but would need a therapist elsewhere. Our depression therapy page has the details.
- Cognitive behavioral therapy (CBT). You learn to challenge and change unhelpful thoughts and behaviors. NIMH names it as an evidence-based therapy for depression, and members of our team use it.
- Mindfulness-based work. NIMH notes that recent advances in CBT add mindfulness principles. Members of our team use mindfulness-based approaches.
Medication groups, in plain words
NIMH says antidepressants work by changing how the brain produces or uses certain chemicals involved in mood or stress. Medication care here is with our psychiatrist, for people in Pennsylvania or New York during each visit. Our therapists do not prescribe. Each medicine has its own page in our medicine library, which separates FDA-approved uses from off-label uses.
- SSRIs and SNRIs. NIMH says these commonly prescribed groups are associated with fewer side effects than older antidepressants.
- NDRIs. Norepinephrine-dopamine reuptake inhibitors are the third commonly prescribed group NIMH lists.
- Atypical antidepressants. MedlinePlus describes these as newer medicines that do not fit the other groups.
- Tricyclics and tetracyclics. These are older types. MedlinePlus says a provider might suggest one if newer medicines do not help, and that they may cause more serious side effects.
- MAOIs. Monoamine oxidase inhibitors are also older. NIMH says they are associated with more side effects, though they may be the right fit for some people.
- Add-on medicines. NIMH says another option for treatment-resistant depression is to combine an antidepressant with a different type of medicine, such as an antipsychotic or anticonvulsant.
- Zuranolone. Its label approves it for postpartum depression in adults. It carries a boxed warning about impaired driving, and the label lists it as Schedule IV.
Treatments an online visit cannot provide
Esketamine (Spravato) is not something an online visit can provide. Its label approves this nasal spray for adults with treatment-resistant depression, on its own or with an oral antidepressant, and, with an oral antidepressant, for depressive symptoms in adults with major depression and acute suicidal thoughts or behavior. It is a Schedule III medicine under a restricted safety program. A certified healthcare setting gives it, under direct observation, with monitoring for at least two hours after each dose, because of risks that include sedation and breathing problems.
Brain stimulation therapy is not online either. NIMH describes it as activating or inhibiting the brain with electricity or magnetic waves, and says the most used types are electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS). They are not something an online visit can provide. A doctor can tell you where they are offered.
For controlled medicines in general: as of November 2026, a temporary federal rule (Federal Register, Fourth Temporary Extension) allows DEA-registered practitioners to prescribe Schedule II to V medicines by audio-video telemedicine without a prior in-person evaluation, under set conditions, through December 31, 2026. Rules may change after that date. That rule does not change the esketamine safety program.
Getting started
If you are in crisis, call or text 988, or call 911. Locascio Wellness does not provide emergency services. Our crisis resources page has more. Antidepressant labels carry a boxed warning that these medicines increased the risk of suicidal thoughts and behaviors in children, teens and young adults. NIMH says this applies to people under 25 and that people of all ages taking antidepressants should be watched closely, especially in the first few weeks.
- Reach outUse our medication care contact form and tell us what you are going through. Ask us about fees, insurance, ages seen and timing, because the answers depend on your situation.
- Meet by videoYou see the psychiatrist from a private spot while physically located in Pennsylvania or New York. You can read more about online psychiatry in Pennsylvania or in New York.
- Decide togetherWhether any medicine is an option for you is a decision for you and your prescriber, and a visit may not end in a prescription. Medication management explains the follow-up visits.
Your psychiatrist
Psychiatric care here is with our psychiatrist, licensed as a physician in Pennsylvania and New York. His license details are on his profile.
Medicines you may hear about for depression
Some are FDA-approved for it and some are used off-label; each page says which, and lists its warnings. Whether any of them is right for you is a decision for you and your prescriber.
- Sertraline (Zoloft)
- Fluoxetine
- Paroxetine (Paxil)
- Citalopram (Celexa)
- Escitalopram (Lexapro)
- Fluvoxamine
- Venlafaxine (Effexor XR)
- Desvenlafaxine (Pristiq)
- Duloxetine
- Levomilnacipran (Fetzima)
- Bupropion (Wellbutrin SR, Wellbutrin XL)
- Mirtazapine (Remeron)
- Trazodone
- Vilazodone (Viibryd)
- Vortioxetine (Trintellix)
- Dextromethorphan and bupropion (Auvelity)
- Gepirone (Exxua)
- Nefazodone
- Amitriptyline
- Nortriptyline
- Imipramine
- Desipramine
- Doxepin
- Phenelzine (Nardil)
- Tranylcypromine (Parnate)
- Isocarboxazid (Marplan)
- Selegiline patch (Emsam)
- Aripiprazole (Abilify)
- Brexpiprazole (Rexulti)
- Quetiapine (Seroquel XR)
- Cariprazine (Vraylar)
- Olanzapine and fluoxetine
- Lithium
- Zuranolone (Zurzuvae)
- Esketamine (Spravato)
Guides
Ready to start
- How to Get Antidepressant Care Online in PennsylvaniaHow to see an online psychiatrist about antidepressants in Pennsylvania: check a license on PALS, confirm coverage, prepare for a video visit and follow up.Read article
- How to Get Antidepressant Care Online in New YorkHow to see an online psychiatrist about antidepressants in New York: verify a license with NYSED, review physician conduct records and prepare for a video visit.Read article
- Switching Antidepressants With an Online PsychiatristWhy people change antidepressants, the records to bring to an online psychiatrist, and why never to change on your own. For readers in Pennsylvania and New York.Read article
- Your First Online Psychiatry Visit for Depression: What to ExpectWhat to bring to a first online psychiatry visit for depression, the safety questions you may hear, and why it may not end in a prescription. For PA and NY.Read article
Comparing your options
- SSRI vs SNRI for Depression: What the Labels SaySSRIs and SNRIs compared for depression: how each is thought to act, labeled uses and side effects, with no ranking. Online care in Pennsylvania and New York.Read article
- Bupropion vs SSRIs: How the Labels DifferBupropion and SSRIs compared without ranking: how each is thought to act, approved uses, and label warnings including seizures. Online care in PA and New York.Read article
- When Your First Antidepressant Does Not HelpIf a first antidepressant has not helped, a prescriber may discuss the dose, a different medicine, an add-on or therapy. General information for PA and NY.Read article
- Depression Medication vs Therapy: What Each Does and How to DecideWhat medication and therapy each do for depression, how they can be combined, and how to decide with a clinician. Online care in Pennsylvania and New York.Read article
Support and resources
- Medications for Depression: The Main Groups ExplainedA plain guide to the main groups of depression medicines, from SSRIs and SNRIs to older types and esketamine, with online care in Pennsylvania and New York.Read article
- How Do Antidepressants Work? What Is Known and What Is NotWhat is known and not known about how antidepressants work, drawn from NIMH and FDA labels, with online psychiatric care in Pennsylvania and New York.Read article
- Antidepressant Side Effects: What to Know and What to ReportCommon antidepressant side effects by group, the boxed warning for people under 25, and what to report right away, with online care in Pennsylvania and New York.Read article
- How Long Do Antidepressants Take to Work?NIMH says antidepressants usually take 4 to 8 weeks to work. What to notice along the way and why stopping suddenly is a problem, for readers in PA and NY.Read article
Questions people ask
Can I get depression care from you if I live in New York?
Yes, for medication care. Our psychiatrist sees people who are physically located in New York or Pennsylvania during each visit. Therapy with our team is not available in New York, because our therapists see clients in Pennsylvania, West Virginia, Arizona, Colorado and Florida. A New York reader who wants therapy as well would need a therapist elsewhere.
Do your therapists prescribe antidepressants?
No. Our therapists do not prescribe. Medication care here is with our psychiatrist, a Doctor of Osteopathic Medicine with more than three decades of practice, for people in Pennsylvania or New York. Outside those two states, medication questions go to your own prescriber. With your permission, a therapist here and the psychiatrist can coordinate your care.
Can I get esketamine or TMS online?
No. The label for esketamine requires it to be given in a certified healthcare setting with monitoring for at least two hours, so it cannot be done by online visit. Brain stimulation therapies such as ECT and rTMS are not something an online visit can provide either. A doctor can tell you where they are offered.
How do online visits for depression work?
You meet by secure video from a phone, tablet or computer, in a private place where you can speak freely. You must be physically located in Pennsylvania or New York during each medication visit. NIMH says psychotherapy can be effective when delivered virtually. A visit is a conversation first, and it may not end in a prescription.
Does insurance cover online depression treatment?
It depends on the plan and on which service you use. Coverage for psychiatry can differ from coverage for therapy. Ask us about fees and insurance before your first medication visit. For therapy, you can ask the practice to verify your benefits.
Are natural products like St. John's wort a treatment for depression?
NIMH says the FDA has not approved any natural products for treating depression, and that these products can come with risks, including interactions with prescription medicines. NIMH also warns that combining antidepressants with St. John's wort can cause a rare but life-threatening illness called serotonin syndrome. Talk to a health care provider before using any of them.
Sources
- National Institute of Mental Health: Depression
- National Institute of Mental Health: Mental Health Medications
- MedlinePlus: Antidepressants
- DailyMed: Spravato (esketamine) prescribing information
- DailyMed: Zurzuvae (zuranolone) prescribing information
- Federal Register: Fourth Temporary Extension of COVID-19 Telemedicine Flexibilities for Prescription of Controlled Medications
Published by Locascio Wellness. Last updated October 9, 2026. Clinically reviewed by Kenneth M. Levy, DO, Psychiatrist (Pennsylvania license OS007464L). This page is general information, not medical advice or a diagnosis.
